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Substractive Genomics Approach to Identify Potential Drug Targets in Streptococcus Pyogens [PDF]

BY: Shilpa Shiragannavar | Category: Bioinformatics | Submitted: 2016-07-25 05:31:48
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Article Summary: "The present study is carried out to identify potential drug targets in Streptococcus species that might facilitate the discovery of novel drugs in near future. Various steps were adopted to find out novel drug targets. susbtractive genomic approach has been used to identify therapeutic target in Streptococcus pyogenes.."


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The present study is carried out to identify potential drug targets in Streptococcus species that might facilitate the discovery of novel drugs in near future. Various steps were adopted to find out novel drug targets. susbtractive genomic approach has been used to identify therapeutic target in Streptococcus pyogenes


INTRODUCTION

The complete genome sequences of many microbes were completed in the past decade. Valuable information on finding the treatment of various infections caused by pathogens can be retrieved using the comparative genomics and subtractive genomics approaches. The critical genes which are crucial for the survival of the pathogens and which are absent in the host can be screened out by using the subtractive genomics approach. The chances of cross reactivity and side effects can be decreased by selecting such non-homologous proteins which are not found in humans. The genes and their products which can be used as a potential drug targets can be identified by analyzing these genes with the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database.







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