Biotech Articles
Publish Your Research Online
Get Recognition - International Audience

Request for an Author Account   |   Login   |   Submit Article
 
 
HOME FAQ TOP AUTHORS FORUMS PUBLISH ARTICLE
 
 

The Role of Endometrial Cells in Treating Cardiac Failure

BY: Meenu Kumar | Category: Biotech-Research | Submitted: 2013-04-26 21:34:32
       No Photo
Article Summary: "Heart failure, as we all know, is one of the major reasons of mortality and morbidity world-wide. Recent findings have stated that heart valve can undergo regeneration, which ideally can eliminate the usage of bovine and porcine valve replacements. This involves the usage of an effective allogeneic product, in conjunction with a.."


Share with Facebook Share with Linkedin Share with Twitter Share with Pinterest Email this article
     


Heart failure, as we all know, is one of the major reasons of mortality and morbidity world-wide. Recent findings have stated that heart valve can undergo regeneration, which ideally can eliminate the usage of bovine and porcine valve replacements. This involves the usage of an effective allogeneic product, in conjunction with an effective delivery system. It was during the year 2007 that ERC, the endometrial regenerating cell, mesencymal type stem cells was discovered. It was immediately concluded that ERCs are far superior than most of the bone marrow stem cells, which is the most commonly deployed source in cell development. ERC is superior in expandability, is involved in the production of a wide range of growth factors and is highly angiogenic in nature. This is conjunction with an ideal delivery system can aid in the rapid regeneration of heart valve cells.

Therapeutic efficiency of the ERCs
The higher degree of angiogenesis that happens in the endometrium led to a high speculation that ERCs play a major role in the physiology of the process. This, supplemented with a high rate of angiogenic factors such as the MMPs, Estradiol and the VEGF aided in the process of the cycle. Further, it was noticed that ovariectomy diminished the production of angiogenesis and VEGF. To further determine the efficacy of the ERCs and to estimate their role in angiogenesis, a murine hind limb ischemia model was created and a group of animals were treated with human ERC, whereas the controls weren't. Results were surprising when levels of anti-inflammatory cytokines where stimulation and inflammatory cytokines were diminished.

The delivery technique
Conventionally, all cell-delivery types, especially the cardiac cells involved intramyocardial, transendocardial or transepicardial, or antegrade mode of delivery into the coronary artery. A few of these routes have the disadvantage of surgical invasion, complex mapping by means of NOGA device, and more. Further, the intramyocardial means of delivery is not ideal for patients with a thin myocardium as it could lead to perforation. Comparatively, retrograde therapy has been used effectively for the delivery of protein and protein-based therapeutics and less in cardiac cell delivery. A porcine study employed the usage of retrograde mode of administration of FGF-2 protein, to prevent the induction of stenosis. Radio-labeled FGF2 showed that twice the level of FGF 2 was absorbed when compared to antegrade mode of infusion. Further, there were significant increases transmural flow of blood and myocardial function.

Another study also suggested the usage of retrograde method to distribute progenitor cells in a rat infarction model. After 28 days, there were significant improvements in cardiac function, decreased fibrosis and increased cell retention.

Retrograde administration coupled with ERC therapy
Several studies have assessed the effectiveness of retrograde mode of administration. For instance, a study involved the retrograde administration of beta-galactase and luciferase in porcine coronary artery. Slight increased levels of gene expression was observed when compared to antegrade method and similar results were also obtained in the interstitial expression of the eGFP in porcine heart that were induced by means of retrograde method along with naked DNA. In another method, B-gal that encodes a plasmid results in higher levels of gene expression when introduced by the retrograde method.

Effective trials were launched in 2012 to examine the efficacy and safety of ERCs in patients suffering from Congestive Heart Failure. Retrograde mode of delivery through the coronary sinuses, by means of minimal invasion, is supportive of efficiency and nearly 60 patients are being studied upon. Congestive Heart Failure was confirmed by means of various cardiac function tests, physician assessments, and patient assessment tests. It also includes symptomatic heart failure and other modes of cardiac interventions. Efficacy end points are obtained after the following time periods; cardiac function is assessed at the end of 3 months, 6 months, and 1 year.

However, despite an effective model, it is important to note that cardiac cell therapy requires highly efficient and scalable methods. ERC is a superior donor when compared to many other types of stem cells and possess exquisite angiogenic properties when compared to many other types of clinical stem cells. The success of the trial entirely depends on results that re further obtained and in the establishment of a regenerative cell therapy that is purely of the cardiovascular type. Indeed, stem-cell based therapies are enticing.

About Author / Additional Info:


Search this site & forums
Share this article with friends:



Share with Facebook Share with Linkedin Share with Twitter Share with Pinterest Email this article

More Social Bookmarks (Digg etc..)


Comments on this article: (0 comments so far)

Comment By Comment

Leave a Comment   |   Article Views: 1702



Additional Articles:

•   Organic Farming - Higher Crop Yield and Eco-friendly to Atmosphere

•   Vaccine Industry in India

•   Bioaugmentation Technology For Cereal Waste Management

•   Research and Development of Bacterial Genomic Size




Latest Articles in "Biotech-Research" category:
•   Human Longevity: A Revolution in Biotechnology and Nanotechnology.

•   Nanoparticles as Delivery Device For Gene Therapy

•   Biotechnology as a Tool in Medicine: Focus on Artemisinin

•   Tissue Cells and Skin Cells Reprogrammed Into Embryonic Stem Cells:-

•   Polymerase Chain Reaction (or PCR) - Technique For Amplifying DNA

•   Treatment of Heart Disease With Stem Cells

•   Biological Activities and Bioassays

•   DNA Sequencing: Maxam Gilbert Method

•   PCR Aspects and its Future | PCR versus Cloning

•   Plasmid as Vectors For Plant Transformation

•   Gene Isolation and Characterisation

•   Apoptosis and Cancer: A Review

•   Extraction of Nucleic Acids (DNA and RNA) From Plant Tissues

•   Stem Cells From Bone Marrow and Vein Leftovers Can Heal Damaged Hearts

•   Gene Transfer Techniques: Biolistics, Bacterial and Viral Transformation

•   Breast Cancer: Cactus For Womens Life

•   Mtt Assay: Assess The Viability Of Cell In Culture

•   Medicinal Plants: Source Of Medicine

•   Biotechnology Impact on Alzheimer's Disease



Important Disclaimer: All articles on this website are for general information only and is not a professional or experts advice. We do not own any responsibility for correctness or authenticity of the information presented in this article, or any loss or injury resulting from it. We do not endorse these articles, we are neither affiliated with the authors of these articles nor responsible for their content. Please see our disclaimer section for complete terms.
Page copy protected against web site content infringement by Copyscape
Copyright © 2010 biotecharticles.com - Do not copy articles from this website.

ARTICLE CATEGORIES :
Agriculture Bioinformatics Applications Biotech Products Biotech Research
Biology Careers College/Edu DNA Environmental Biotech
Genetics Healthcare Industry News Issues Nanotechnology
Others Stem Cells Press Release Toxicology  


  |   Disclaimer/Privacy/TOS   |   Submission Guidelines   |   Contact Us