Biotech Articles
Publish Your Research Online
Get Recognition - International Audience

Request for an Author Account   |   Login   |   Submit Article
 
 
HOME FAQ TOP AUTHORS FORUMS PUBLISH ARTICLE
 
 

Low Fat Diet to Reduce Risk of Breast Cancer.

BY: Sandhya Anand | Category: Press-Release | Submitted: 2013-12-04 13:05:03
       No Photo
Article Summary: "Two separate team of researchers have found a metabolite of cholesterol to be behind the risk of cancers especially those which are estrogen driven. The mechanism of action is similar to that of estrogen and inhibitors for the metabolite formation (statins) can therefore be alternate therapeutic possibilities..."


Share with Facebook Share with Linkedin Share with Twitter Share with Pinterest Email this article
     


Just like smoking, obesity has been in the bad light for being one of the risk factors for several diseases including cancer. However, the exact link and mechanism has not been well understood till two teams of researchers under the leadership of Donald McDonnell at Duke and Philip Shaul of University of Texas explored to find out the role of 27-hydroxycholesterol in spurting cancer growth. Their research has revealed the effect of 27-hydroxy cholesterol to be similar to that of estrogen in promoting cancer growth.

The finding is crucial since a low fat diet with less cholesterol can thus lessen the risk of cancer. The role of estrogen in promoting the cancer growth especially in breast cancer has been previously established. The fat tissue has also been proved to promote the production of estrogen. The current research has revealed a completely different mechanism involving the cholesterol directly (27 HC is one of the cholesterol metabolite) which function exactly like estrogen in promoting the cancer growth.

In women past the menopause, the risk should be significantly lower due to the absence of estrogen production. However, this new method of alleviating the risk of cancer through cholesterol seems to be a plausible explanation for the prevalence of breast cancer even in menopausal women.

In the finding published in the journal science, it is reported that human breast cancer cells were found to grow faster in vitro conditions when 27 Hydroxy Cholesterol (27 HC) was added. The compound was also found to cause similar effects in mice in which human cancer cells had been implanted or genetically engineered to carry genes responsible for breast tumour. The research by Mc Donnel's team also revealed the ability of 27 HC to increase the metastasis.

Shaul's team conducted studies in women who were affected. When breast tissue samples of affected women were checked, it was found to have more 27 HC than unaffected women of the control group. The team was also able to zero in the enzyme responsible for the conversion of cholesterol to 27 Hydroxy cholesterol to be CYP27A1. Inversely, when the enzyme responsible for the breakdown of 27 HC, i.e; CYP7B1 was low, the survival period of affected women were significantly lowered. In severe cases, the amount of CYP27A1 was higher.

Thus, researchers were able to establish the role of 27 HC in causing and spreading cancer especially even when estrogen levels were lower thus providing an alternative route and risk in estrogen dependent tumours.

Mc Donnel and his team conducted further experiments in mice for understanding the exact mechanism. Genetically altered mice with implanted breast cancer cells were fed with a high fat diet and were found to carry more blood cholesterol as well as more 27 HC. The tumours which developed in such mice were also 30 % larger after a period of 15 days when compared to control group. Statins for lowering blood cholesterol were found to be effective in blocking the development of tumours.
Statins are drugs which are used to control blood cholesterol levels in obese patients. These drugs along with dietary modifications can therefore reduce the risk or slower the development of tumour especially in those which are estrogen dependent like breast cancer. This also provides the reason for non effectiveness of aromatase inhibitors which inhibit production of estrogen in some breast cancer patients. Statins or similar inhibitors of CYP27A1 can therefore be an ideal replacement for such patients.

Further studies are needed to reveal the link between 27 HC and other hormone dependent or hormone-driven cancers. Shaul's team has found that endometrial cancer cells too proliferate faster when supplied with 27 HC in petridish.

About Author / Additional Info:
References
1. JOCELYN KAISER; Cholesterol Forges Link Between Obesity and Breast Cancer; 29 NOVEMBER 2013 VOL 342 SCIENCE www.sciencemag.org
2. Mc Donnel; 27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology; Science 29 November 2013: Vol. 342 no. 6162 pp. 1094-1098
3. http://www.cell.com/cell-reports/fulltext/S2211-1247%2813%2900575-5

sandhyampanand@gmail.com

Search this site & forums
Share this article with friends:



Share with Facebook Share with Linkedin Share with Twitter Share with Pinterest Email this article

More Social Bookmarks (Digg etc..)


Comments on this article: (0 comments so far)

Comment By Comment

Leave a Comment   |   Article Views: 1575



Additional Articles:

•   Nutrients Variability in Sohiong (Prunus Nepalensis L.) Fruit

•   Laboratory Data For Blood Test

•   Double Haploids: A Promising Tool in Plant Breeding

•   Laboratory Data For Blood Test




Latest Articles in "Press-Release" category:
•   Publish Your Biotechnology Press Releases on BiotechArticles.com

•   Ginger Technology (Cures for all diseases)

•   International Stem Cell Corporation Announces the Commercial Launch of New Skin Care Products

•   Greiner Bio-One in Monroe, NC Opens New Warehouse Facility

•   MMS Hosts 2011 Scientific Symposium

•   Treatment of Domestic Waste Water Using Natural Horse and Cow Dung

•   Genotypic and NIPGR Launch Chickpea Gene Expression Microarray

•   Epigentek Introduces a Cost-Effective and Reliable Means to Validate Antibodies for ChIP



Important Disclaimer: All articles on this website are for general information only and is not a professional or experts advice. We do not own any responsibility for correctness or authenticity of the information presented in this article, or any loss or injury resulting from it. We do not endorse these articles, we are neither affiliated with the authors of these articles nor responsible for their content. Please see our disclaimer section for complete terms.
Page copy protected against web site content infringement by Copyscape
Copyright © 2010 biotecharticles.com - Do not copy articles from this website.

ARTICLE CATEGORIES :
Agriculture Bioinformatics Applications Biotech Products Biotech Research
Biology Careers College/Edu DNA Environmental Biotech
Genetics Healthcare Industry News Issues Nanotechnology
Others Stem Cells Press Release Toxicology  


  |   Disclaimer/Privacy/TOS   |   Submission Guidelines   |   Contact Us