Under the assistance of a growth factor, a new stem cell technique not only can regenerate the injured tissue, but also can be applied as a regenerative medicine. And most importantly, it's proved effective on rodents with objective evidence. And the clinical trial on human is set to be launched before 2018, making the therapy an advanced version of the presently available stem cell therapies.
The latest research was carried out by scientific team from the University of New South Wales and the related paper was published on the journal of National Academy of Sciences.
The new tech employs reprogrammed bone and fat cells to induce multipotent stem cells by working with platelet-derived growth factor-AB (PDGF-AB) and 5-Azacytidine and then achieve the aim of boosting multiple tissue regeneration, which is different from the conventional stem cells therapies regenerating tissues by applying oriented stem cells for a specific tissue with narrow choice on the starting cells for different tissues, involving great difficulty on operation.
The main distinction is the staple stem cells applied. For the traditional therapies, adult stem cells which are only capable of regenerating one type of tissue, while multipotent stem cells hinting like its literal meaning can generate various tissues.
Applying common fat cells to make the multipotent stem cells makes the therapy easier to be accessed and can be applied in may practical situations, like bone pain to replace the ineffective spinal implantations.
The new tech is of great significance in providing an effective and economic treatment for tissue injured illness. At present the team is studying the safety of the multipotent stem cells induced from adult fat stem cells. Once the reprogrammed cells are proved safe to be applied in such therapies, the clinical trial on human will be carried within two years.
The paper of the research is titled as PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells with the doi number being 10.1073/pnas.1518244113.
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