Lipase is lipolytic enzyme that leads lipolysis to degrade dietary fats in to fatty acid and glycerol which is absorbed in the intestines. Mostly lipases are produced by the pancreas, though they are also produced in other parts of the body as well, including the stomach, liver and salivary glands. Hence, we can say, lipase is primarily produced in the pancreas as well as in the mouth and stomach. The patients of cystic fibrosis, Crohn's disease, and celiac disease may not have enough pancreatic lipase. Celiac disease is a pathological condition in which gluten damages the intestinal tract with the occurrence of abdominal pain, bloating, weight loss, and fatigue. Patients of celiac disease must follow a strict diet without gluten. In case study of 40 children with celiac disease, the supplementation of pancreatic lipase was given as therapy which lead to modest weight gain compared to those who received placebo. People with cystic fibrosis is an inherited pathological condition that causes the body to produce abnormally thick, sticky mucus because mucus blocks pancreatic lipase to pour in to intestines. Its primary dietry source is in the pancreas and is not found in food. Lipase supplements are usually found in animal enzymes, as compared to plant sources. Lipase may be taken in combination with protease and amylase enzymes especially in tablet and capsule form. Side effects of oral administration may include nausea and stomach upset as well as high doses of lipase may lead to cystic fibrosis. Pancreatitis is a pathological condition of inflammation of the pancreas which leads to effect on production of pancreatic lipase in the body. There are several possible causes for pancreatitis, including excessive consumption of alcohol, gall stones or infection and hepatic carcinoma. It can lead to high amounts of pancreatic lipase in the blood. Too few lipases in the body can cause several issues. Sometimes, highly active lipases lead to breakdown of fats in to high levels of cholesterol and triglycerides in their blood which ,in turn, may cause in troubling of losing weight especiaaly in patients of heart diseases and diabetes. In the prolonged use of oral administration of lipase may be responsible for muscle, colon spasms and certain genetic conditions.

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Dr. Kirti Rani Sharma,
Assistant Professor (II),
Amity Institute of Biotechnology,
Amity University Uttar Pradesh, Noida
Sec-125, Gautam Buddha Nagar, Noida-201303 (UP), India.
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