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Most Recent Bioinformatics Articles.
  • Normalization in Microarray Data Analysis and types of Normalization Methods    By: Nivedita Yadav

    The term normalization has been linked to microarray data as the first step in the data analysis and plays important role in the analysis, many undesirable systematic variations are commonly observed during data analysis in Microarray. There are many type of Normalization Methods. >> Category: Bioinformatics
  • Methods of Prediction of Secondary Structures of Proteins    By: Shilpa Shiragannavar

    Protein secondary structure prediction refers to the prediction of the conformational state of each amino acid residue of a protein sequence as one of the three possible states, namely, helices, strands, or coils, denoted as H, E, and C, respectively. The prediction is based on the fact that secondary structures have a regular arrangement of amino acids, stabilized by hydrogen bonding patterns. >> Category: Bioinformatics
  • Can Mycobacterium Tuberculosis be Starved to Death?    By: Vipin Chandra Kalia

    Mycobacterium tuberculosis is a pathogen, which causes tuberculosis resulting in millions of human deaths every year. Attempts to treat tuberculosis with increasing and persistent doses of antibiotics have proved counterproductive. The undue stress caused by heavy doses of antibiotics induced bacteria to evolve and become multi-drug resistant. Comparative genomic reveals a few novel drug targets to contain the disease. >> Category: Bioinformatics
  • Can Bacteria Produce Blockbuster Antibacterial: The Penicillin?    By: Vipin Chandra Kalia

    Indiscriminate usage of antibiotics has resulted in emergence of multi-drug resistant microbes. Shall we look for novel antibiotics / producers, and /or transform presently non-producers to producers by genetically modifying the antibiotic production machinery? Comparative genomics reveal bacteria can produce antibiotic - penicillin. >> Category: Bioinformatics
  • Microarray Informatics Approach to Find Drug Targets in Prostate Cancer    By: Shilpa Shiragannavar

    Systematic approach for drug discovery is an emerging discipline in systems biology research area. It aims at integrating interaction data and experimental data to elucidate diseases and also raises new issues in drug discovery for cancer treatment. Many studies have used DNA microarrays to identify the gene expression signatures of human cancer, yet the critical features of these often unmanageably large signatures remain elusive. The regulation of gene expression is a dynamic process, hence it is of vital interest to identify and characterize changes in gene expression over time. >> Category: Bioinformatics
  • Substractive Genomics Approach to Identify Potential Drug Targets in Streptococcus Pyogens [PDF]    By: Shilpa Shiragannavar

    The present study is carried out to identify potential drug targets in Streptococcus species that might facilitate the discovery of novel drugs in near future. Various steps were adopted to find out novel drug targets. susbtractive genomic approach has been used to identify therapeutic target in Streptococcus pyogenes >> Category: Bioinformatics
  • Databases for Genes Involved in Stress Mechanism in Plants    By: Dr. Dhammaprakash P Wankhede

    Different Biotic and abiotic stresses are among the major constraints in improving crop productivity. Several genes involved in stress tolerance mechanisms have been identified in plants and databases developed for stress responsive genes and stress conditions. This article gives information about important databases dedicated for genes involved in stress mechanisms. >> Category: Bioinformatics
  • Main Four Parts Services in Bioinformatics Services    By: Mandy Scott

    As the rapid development of life sciences and computer science, bioinformatics becomes a new subject in collection, process, storage, transmission, analysis and interpretation of biological information. >> Category: Bioinformatics
  • Transcriptomics sequencing and lncRNA Sequencing Analysis: Quality Evaluation and Genome Alignment    By: Sherry Green

    The data analysis of transcriptomics sequencing and lncRNA sequencing is the key element of successful interpretation of sequencing. And the quality evaluation and genome alignment are the bases for the data analysis. >> Category: Bioinformatics
  • Common Q&A for Sequencing    By: Sherry Green

    This is an article about the common question for sequencing. I select them and I think they are useful for your doubt. >> Category: Bioinformatics
  • Environmental Informatics and its Applications    By: Fayaz Ahmad Malla

    Environmental informatics is the science of information applied to environmental science. As such, it provides the information processing and communication infrastructure to the interdisciplinary field of environmental sciences aiming at data, information and knowledge integration, the application of computational intelligence to environmental data as well as the identification of environmental impacts of information technology. The UK Natural Environment Research Council defines environmental informatics as the "research and system development focusing on the environmental sciences relating to the creation, collection, storage, processing, modelling, interpretation, display and dissemination of data and information". Environmental informatics emerged in early 1990 in Central Europe. >> Category: Bioinformatics
  • Bioinformatics Sequence Databases    By: Madhu Bala Priyadarshi

    In the current scenario, biological data is so huge that biologists depend on databases to store, organize, search and analyze data. In DNA databases efforts are made to store data of DNA sequences which are potentially useful for computation. With the fast pace of advancement of technology in the field of bioinformatics, India is not behind from other countries. Substantial efforts have been done to store sequence data. There are several databanks and softwares available on internet for retrieving information and among them, GenBank/EMBL/DDBJ databank stores largest number of records. >> Category: Bioinformatics
  • Applications of Bioinformatics    By: Madhu Bala Priyadarshi

    Today, bioinformatics is used in large number of fields such as microbial genome applications, biotechnology, waste cleanup, Gene Therapy etc. In this article an effort is made to provide brief information of applications of bioinformatics in the field of Medicine, Microbial Genome Application and Agriculture. >> Category: Bioinformatics
  • Genome Sequencing Strategies    By: Nandan Nair

    Sequencing a genome is an enormous task. It requires not only finding the nucleotides sequence of small pieces of genome but also ordering those small pieces together into the whole genome. In 1975 Frederick Sanger developed a technique which was most widely used for DNA sequencing. He used dideoxynucleotide triphosphate (ddNTPs) in DNA synthesis. Recently automated system for DNA sequencing has been developed. Where ddNTPs are labeled with fluorescent dyes, each of different colours which are scanned by a detector and sequence is determined from the order of colour formed in band on gel. >> Category: Bioinformatics
  • Comparative N-linked Glycosylation site Analysis    By: Hareepriyaw M

    Glycosylation is one such modification that supplements the protein structure with various oligo-saccharides. Comparative N-linked Glycosylation site analysis and their prediction in eukaryotes. >> Category: Bioinformatics
  • In-Silico Methods For Identifying Active Enhancers    By: Hareepriyaw M

    In-Silico methods for identifying active enhancersIn-Silico methods for identifying active enhancersIn-Silico methods for identifying active enhancers >> Category: Bioinformatics
  • DNA Barcoding: Differentiation of Boerhaavia Diffusa From Other Species    By: Hareepriyaw M

    A technique called internal transcribed spacer (ITS) DNA Barcoding is applied to discriminate Boerhaavia diffusa from its other species. Adulteration of B.diffusa with other species of Boerhaavia like B.erecta, B.coccinea, B.repanda and B.verticillata are commonly observed. >> Category: Bioinformatics
  • PepBind - A Database and Protein-peptide Interaction Analysis Tool    By: Hareepriyaw M

    The PepBind database aids in the exploration of the interactions between peptide and protein through computational evaluation of various interactions. It also helps in providing structural information of these interactions in the text format as well as in 3D format on the screen. PepBind database harbors the coordinates of the protein structure, protein-peptide interaction data files formed by PICI and PDBML data files. PepBind provides the structural, functional and source data for studying the interactions of peptide binding proteins. >> Category: Bioinformatics
  • Low DNA Damage Repair Capacity of Induced Pluripotent Stem Cells    By: Hareepriyaw M

    Embryonic stem cells (ESCs) are considered pluripotent and are capable to give rise to all types of somatic cells. This ability of ESCs can be utilized in treating certain diseases. ESC like pluripotent stem cells were created successfully in a research work published in 2006 and they were termed as induced pluripotent stem cells or iPSCs. The iPSCs were possible when four transcription factors called Oct4, c-Myc, Sox2 and Klf4 were introduced into somatic cells of mice. The newly created iPSCs were same as ESCs in their gene expression, morphology, In Vitro differentiation capacity and in epigenetic status. Many studies say that iPSCs are not beneficial clinically due to their genomic instability. >> Category: Bioinformatics
  • Identification of Biomarkers for Lupus Nephritis    By: Hareepriyaw M

    Lupus nephritis is kidney inflammation caused by systemic lupus erythematosus. Systemic lupus erythematosus or SLE is an autoimmune disease which is characterized as producing autoantibodies against the antigens like histones, RNA and DNA. >> Category: Bioinformatics
  • Gas Medium for Plant Nutrition in Greenhouses    By: Hareepriyaw M

    The novel technologies used in greenhouses offer an effective method of producing vegetables and crops, which consist of micro elements and macro elements required for the utility of human being. The production of the crops as part of the technology can be intensified by providing mineral fertilizers that can provide extra nutrition to the roots and leaves of the plants. >> Category: Bioinformatics
  • Computational Simulation and Performance Analysis of MHC Peptide Binding    By: Sachin N. Dharurkar

    The immune system is a defense system that is present in vertebrates to protect them from invading pathogens and cancer. The protection against foreign molecules (antigens) can be both specific and non specific. Non-specific immunity includes, for example, skin (as a physical barrier), mucous membranes and inflammation. Specific immunity allows the organism to specifically recognize and selective >> Category: Bioinformatics
  • Job Prospects in Bioinformatics    By: Maitree Baral

    Bioinformatics as an emerging interdisciplinary subject has varied prospects. If you are interested in grabbing a job and want to pursue your higher studies or want to do more research on the subject, then there is also scope for the research in medical, biomedical and the molecular biology. >> Category: Bioinformatics
  • Basic Information Regarding Bioinformatics For Beginners    By: Maitree Baral

    Bioinformatics as a research oriented career is less known than its counterparts. Here's a brief review of the various aspects of Bioinformatics in terms of its scope as a career. >> Category: Bioinformatics
  • Nanotechnology and its Application in Crop Improvement Programme    By: Vikas Kumar

    Similar to the concept of the 'electronic nose', researchers are developing an 'electronic tongue' with sensors comprised of small electrodes coated with a polymer to detect small amounts of a wide range of chemicals, such as gases released when food is spoiled (Gardner, 2002). This electronic sensor strip can potentially be incorporated into food packages, which will change in colour when the food product is no longer fit to consume. >> Category: Bioinformatics
  • Popular Applications of Bioinformatics    By: Dilruba Peya

    Bioinformatics is the application of IT in biotechnology (BT) for data storage and analyzing DNA sequences. In Bioinformatics, the knowledge of various branches is needed like biology, chemistry, mathematics, computer science, & laws of physics, and certainly sound knowledge of IT field to analyze biotech data. >> Category: Bioinformatics
  • Structural Biology and Drug Design    By: Geetanjali Murari

    The field of bioinformatics has made the tiring task of drug designing quite easy and time saving. The example of designing drug for HIV protease target is also mentioned in the given article. Through this article I have illustrated the drug-receptor interactions, modelling of 3D molecular structure of proteins. >> Category: Bioinformatics
  • Bioweapons: A New Type of Weapons For Modern Warfare    By: Dilruba Peya

    Bioterrorism is the application of a bioweapon against a civilian population. Its purposes include achieving political goals, creating chaos, or the undermining of morale. Bioweapons use toxins and microorganisms to create disease and death in humans, crops, and livestock. >> Category: Bioinformatics
  • Computer-Aided Molecular Modelling    By: Geetanjali Murari

    This article depicts about the molecular structures of proteins. The three dimensional structure of proteins is studies by using different tools of bioinformatics. The article also throws light on docking, CADD research, primary and quaternary structures of proteins and the drug designing techniques. >> Category: Bioinformatics
  • A Short Story on Metagenomics    By: Shanky Bhat

    Metagenomics a gateway to study uncultured microorganisms. The term metagenomics can be defined as the complete genomic analysis of the environmental sample. Our environment is rich source of microbes be it any condition, microbes are able to survive, this quality make them unique in their own way. >> Category: Bioinformatics
  • Computer Aided Drug Design (CADD) : Concepts and Application    By: Shivani Sharma

    A Deep Insight to Ligand-based Computer-Aided Drug Design. With the continuously increasing need for new drugs, bioinformatics has opened the doors to computer aided drug design (CAD) which provides the development of novel therapeutic drugs. The drugs we see today in market are being improved with the use of CAD and new and better medicinal drugs are being developed keeping in mind the needs of the time. >> Category: Bioinformatics
  • In Silico Designing of RNA Aptamers    By: Shivani Sharma

    RNA molecules are important cellular molecules and their aptamers are basically are in a wide use these days. Aptamers are peptide molecules that bind to a given specific target molecule. Understanding their basic mechanism, processes and creation of RNA aptamers is where the concept of in silico designing comes into the picture In silico designing of RNA aptamers has gained much achievement due to the use of easy to use and apply bioinformatics tool. >> Category: Bioinformatics
  • Male-Biased Nature of Boule and Application of Computer-Aided Drug Design    By: Shivani Sharma

    Boule gene is unleashing new insights into male contraception and child birth. Information on CAD Drug designing in male contraceptive pills. The function of boule though seems to be conserved but is found to be divergent in fish Medaka which shows the expression of boule in both ovaries and sperms thus raising the question if the function and expression of boule is conserved too or has diverged despite the presence of highly conserved RRM sequence. >> Category: Bioinformatics
  • Virtual Screening- a Promising Approach to Drug Discovery    By: vanika garg

    Drug discovery and development is a chain process starting with target and lead discovery, followed by lead optimization and then clinical studies. It is the fastest growing industry. So the need of finding possible drug candidate is increasing exponentially. Out of number of techniques available,VS is increasingly gaining acceptance as it is a very reliable, cost-effective and time saving process >> Category: Bioinformatics
  • Key Concepts of Nanotechnology - Its Applications and Tools    By: Syed Amir Manzoor

    The article focuses on the key concepts, applications and major tools associated with the science of nanotechnology. >> Category: Bioinformatics
  • SYMBIOmatics: Synergies in Bioinformatics and Medical Informatics    By: atisha jain

    This article is about the synergy i.e the integration between two different fields: Bioinformatics (BI) and Medical informatics (MI). Symbiomatics is a project which was started with an objective to identify the links and potential synergies between the bioinformatics and medical informatics research areas >> Category: Bioinformatics
  • Personalized Medicine: Customised Medicines For Your Specific Genes!    By: anisha kathpalia

    Each individual is unique. This uniqueness is due to the difference in our genetic makeup. These variations affect our health and susceptibility to a disease. So why use the same medicine or treatment for everyone? This introduces the concept of personalized medicine which means developing medicines based on the genetic characters of the people. This is still a concept, but will be a reality soon!!! >> Category: Bioinformatics
  • Impact of Whole Genome Sequencing    By: anisha kathpalia

    Whole genome sequencing is determining the sequence of the entire genome of an organism.Different organism's genomes have been sequenced including that of human.Different bionformatics tools & databases are used for browsing & analysing the genome sequences.This whole genome sequence has helped in different aspects of biotechnology including disease diagnosis,crop improvement,cancer research etc >> Category: Bioinformatics
  • GWAS - The New Age of Genomic Studies    By: Sandhya Anand

    GWAS stands for Genome Wide Association Studies. With the availability of Human Genome sequence, Genome Wide Association Studies are being increasing used to explore the association between genotypic variations and phenotypical characters. The article explore the concept, and tools associated with GWAS. >> Category: Bioinformatics
  • Bioinformatic Approaches to Find Gene-genome Duplication    By: Sandhya Anand

    The article discusses the importance of detection of orthologs and bioinformatic methods used in the process. >> Category: Bioinformatics
  • Artificial Neural Networks - Thinking Made Easy For Robots    By: Sandhya Anand

    Artificial neural networks are inspired greatly by the biological processes. These processes try to mimic the working process and pattern of the biological counterparts. The article presents an overview of the basis, function and different networks involved in the process. >> Category: Bioinformatics
  • Knowing You Hormones    By: Zandro Cabaral

    This article summarized the different hormones that controls our body's functions. Hormones are substances that control the functions of the different systems of our body. They are secreted either by the exocrine glands such as the pancreas and the endocrine glands such as the liver. >> Category: Bioinformatics
  • Know Your Vitamins - Part 2    By: Zandro Cabaral

    This is a continuation of my previous article about vitamins. Vitamin B12 or Cobalamin binds to intrinsic factor for absorption. Deficiency results from decreased parietal cell secretion of intrinsic factor in the stomach, causing pernicious megaloblastic anemia. >> Category: Bioinformatics
  • Knowing Your Vitamins - Part 1    By: Zandro Cabaral

    This article gives you a brief knowledge about the different vitamins and hormones in our body. This also includes the classifications of the different vitamins and hormones. >> Category: Bioinformatics
  • Prokaryotic Protein Synthesis    By: Zandro Cabaral

    A summary of the protein synthesis in prokaryotes or single celled organisms. Each type of amino acid is activated by joining to Adenosine Triphosphate using a specific aminoacyl - transfer RNA synthetase. This process is called the Activation with ATP. >> Category: Bioinformatics
  • Mutations Caused By Antibiotics    By: Zandro Cabaral

    Mutations are the result of changes in the messenger RNA codon nucleotide sequence. The shift in the reading frame of the entire DNA chain after the mutation is called a Frameshift mutation. >> Category: Bioinformatics
  • The Prokaryotic And Eukaryotic Rna And Polymerase    By: Zandro Cabaral

    This article is related to my my present research on biochemistry which is about nucleic acids. There is only one RNA polymerase in prokaryotes. This is a Deoxyribonucleic Acid-directed RNA polymerase. >> Category: Bioinformatics
  • Deoxyribonucleic Acid Synthesis - Mechanisms of DNA Repair    By: Zandro Cabaral

    The DNA polymerase III also proofreads the newly synthesized strands removing any incorrect nucleotide and inserting the correct one. This enzyme is supposed to correct the 1/10,000 mutations occurring during DNA replication >> Category: Bioinformatics
  • Deoxyribonucleic Acid Synthesis - DNA Synthesis    By: Zandro Cabaral

    This is a summary on the synthesis of DNA in the body. An overview of my own research in Biochemistry. >> Category: Bioinformatics
  • How Nucleosides Form to Nucleic Acids    By: Zandro Cabaral

    the article is all about how simple nucleosides form into nucleic acids. the an overview of my on going research in biochemistry. >> Category: Bioinformatics

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