Pearl millet is considered staple food in many parts of India as well as World. This can be used as a valuable animal fodder. Insect-pests, diseases and weeds are major constraints in achieving the yield potential of pearl millet. In this article, a detailed emphasis has been given on various insect-pests, diseases and weeds infesting pearl millet crop in the field at various stages, symptoms and extent of damage, bionomics and economic threshold of pests and their management. Besides, storage insects-pests of pearl millet and their management has also been described in detail. This article may certainly be helpful to teachers, students, extension worker, researchers, farmers and other stakeholders associated with pear millet production, storage, distribution, sale and uses.