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Author: Vipin Chandra Kalia

No Photo Total Articles: 16 | Total Views: 11600 | Points Scored: 19,600

City: New Delhi | State: Delhi, India

About Me: Researcher at Microbial Biotechnology and Genomics at CSIR-IGIB, Delhi.

Articles by Vipin Chandra Kalia:
  • Biomedical Applications of Bioplastics ( 157 reads)   

    Microbes operate certain metabolic pathways only when they encounter unfavourable environmental conditions. The most efficient energy generation metabolic pathway is the Tricarboxylic acid cycle (TCA). However, if bacteria sense the presence of excessive amounts of Carbon (C) in their vicinity, they divert their TCA cycle towards bioplastic (Polyhydroxyalkanoates (PHA)) biosynthesis. Although microbes use PHAs as energy reservoir. However, because of their unique physico-chemical properties, they can be used to replace synthetic plastics. - Category: Environmental Biotechnology
  • The Nature's Novel Ways To Genetically Modify Organisms ( 503 reads)   

    Transmission of genetic material from parents to off springs is termed as vertical inheritance. In contrast, Nature allows transfer of genes among distantly related organisms and the pattern is called as Horizontal inheritance or Horizontal Gene Transfer (HGT). HGT allows rapid evolution of organisms especially to confer the recipient organism an ability to withstand environmental stress. It is Nature's way to preserve genetic material of the donor, in case it gets into catastrophic environments. - Category: Environmental Biotechnology
  • The Dawn of Novel Drug Targets and Drugs ( 549 reads)   

    Bacteria seem to be a constant threat to the existence of human beings. We search anti-bacterials to attack bacteria and they develop resistance. No body is winning this battle. The best way is to let bacteria grow and stop their pathogenecity. Here, are the novel tools to achieve this: Live and Let Live - Fool the bacteria and save yourself. - Category: Environmental Biotechnology
  • Emerging Green Technologies for Processing Oil-seeds ( 692 reads)   

    The demand for edible oils is increasing globally but the supply is limited. The limiting factors are: (i) land availability (ii) inefficient extraction processes. Among the methods used for oil extraction, solvent extraction is easy and instant but is limited by the high solvent cost and adds to environmental hazards. The use of green solvents and enzymes can overcome the problems of air pollution, toxicity and process inefficiency. - Category: Environmental Biotechnology
  • Dig out to Fight out Staphylococcus: The Genomic Route ( 458 reads)   

    Staphylococcus is the route cause of diseases such as cellulitis, boils, food poisoning, impetigo, toxic shock syndrome. In general, these bacteria don't cause disease. Physically the infection can be seen as collection of pus, tender, painful reddened and swollen skin area. The most notorious of this group is known as MRSA (Methicillin-resistant Staphylococcus aureus). For proper treatment, correct identification and diagnosis are a must. - Category: Environmental Biotechnology
  • Biodegradable Plastics: Natural versus 'Synthetic' ( 1016 reads)   

    Plastics are one of the most widely used non-biodegradable synthetic chemical products. Microbes under stressed environmental conditions can produce natural bioplastics (polyhydroxyalkanoates, PHAs), which are completely degradable. In contrast, there are 'synthetic' bioplastics, which are prepared by mixing chemicals and biological materials. Here, degradation is limited to the contribution of biological matter. - Category: Environmental Biotechnology
  • The Struggle to Fish Out the Dreadful Streptococcus ( 625 reads)   

    Bacterial diseases causing high morbidity and mortality rates are dreaded by all. Pnuemonia, Otitis Media, Meningitis and Bacteremia are associated with drug resistant Streptococcus species. These bacteria spread rapidly and lead to fatal situations. The causal organism Streptococcus needs to be fished out with precision and treatment must be initiated quickly to prevent the spread of the disease. - Category: Environmental Biotechnology
  • A Friend Among Foes: Lactobacillus ( 785 reads)   

    Lactobacillus strain in small numbers act as probiotics and prove helpful to human beings. It enables easy uptake of nutrients, consumption of milk, treating unhealthy conditions and activate the human immune system. Food Industries are the most worried of contamination of good with bad bacteria. In order to maintain quality and take maximum advantage of the potential health benefits bestowed by Lactobacillus, they must be monitored and identified properly. - Category: Environmental Biotechnology
  • Searching the Dreadful Yersinia in a Crowd ( 737 reads)   

    Yersinia infection is lethal to human beings. It is one of the most dreadful pathogens. The need is to identify them and initiate the treatment before it is too late. Culture techniques are the best but not rapid. Molecular techniques based on 16S rDNA (rrs) gene analysis are limited by the presence of 6-7 copies of this gene/genome. Many other genes have been employed for identifying Yersinia, however there is no consensus. Comparative genomics has revealed consensus genes with unique properties to search Yersinia in a crowd. - Category: Environmental Biotechnology
  • Diagnostic Biomarkers in the Taxonomically Oversized Genus - Clostridium ( 784 reads)   

    The genus Clostridium is composed of bacteria having great biotechnological and medical significance. The genus encompasses around 110 species with a G+C content ranging from 24-58 mol%. The identification of the Clostridium strains is complicated by the multiple (9-22) copies of 16S rDNA (rrs) (the most commonly used gene for bacterial identification) per genome. Novel genomic approaches reveal biomarkers for easy identification and rapid diagnosis. - Category: Environmental Biotechnology
  • Potential of Stenotrophomonas for Bioremediation of Recalcitrant Pollutants ( 806 reads)   

    Environmental pollution is caused by heavy use of highly recalcitrant organic compounds -insecticides and pesticides - Classified as priority pollutants by USEPA. Major causes of concern are: (i) Groundwater pollution, (ii) Toxic accumulation in food chain, (iii) Great ecological imbalance, (iv) Carcinogenic nature. Consequently poisoning leads to 2,00,000 deaths annually. Stentrophomonas has the potential for bioremediation of these recalcitrant pollutants. - Category: Environmental Biotechnology
  • Bacillus - Industrial Work-Horse of the Microbial World ( 845 reads)   

    Bacillus is well recognized for its ability to produce a wide range of enzymes and bioactive molecules with numerous biotechnological applications. Recent research works on this Industrial Work-Horse of the Microbial World have elucidated a few of its novel and latent talents: (i) Biofuel generator, (ii) Biodegradable plastics producer, and (iii) as Antipathogens. - Category: Environmental Biotechnology
  • Can Mycobacterium Tuberculosis be Starved to Death? ( 786 reads)   

    Mycobacterium tuberculosis is a pathogen, which causes tuberculosis resulting in millions of human deaths every year. Attempts to treat tuberculosis with increasing and persistent doses of antibiotics have proved counterproductive. The undue stress caused by heavy doses of antibiotics induced bacteria to evolve and become multi-drug resistant. Comparative genomic reveals a few novel drug targets to contain the disease. - Category: Bioinformatics
  • Can Bacteria Produce Blockbuster Antibacterial: The Penicillin? ( 764 reads)   

    Indiscriminate usage of antibiotics has resulted in emergence of multi-drug resistant microbes. Shall we look for novel antibiotics / producers, and /or transform presently non-producers to producers by genetically modifying the antibiotic production machinery? Comparative genomics reveal bacteria can produce antibiotic - penicillin. - Category: Bioinformatics
  • The Battle: Microbes versus Vaccines, Antibiotics and Antipathogens ( 890 reads)   

    The ubiquitous nature of microbes reflects upon their metabolic diversity and ability to evolve rapidly to counter any environmental stress. They are bestowed with a unique arsenal to infect eukaryotic cells leading to the disease condition. Strategies have been developed to fight diseases: (i) vaccines to prevent bacterial attack, (ii) antibiotics to kill bacteria, and (iii) antipathogens, to prevent them from becoming virulent. - Category: Environmental Biotechnology
  • Biodiesel Industry Waste: Bane or Boon ( 1203 reads)   

    Biodiesel is an efficient substitute for conventional and non-renewable petroleum diesel. It is less polluting and cheaper than petro-diesel. However, for every 10 tonnes of biodiesel produced, 1 tonne of glycerol rich effluent needs to be disposed. Interestingly, the effluent can be metabolized into valued added products such as butanediol, biohydrogen, bioplastics, etc. - Category: Environmental Biotechnology

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